炎症性肠病的病程是相当多样且不可预测的。
翻译丨医院消化科郭红
来源｜医学界消化频道（CCCF—IBD学习驿站出品）
WhatCanWeLearnfromEpidemiologicalStudiesinInflammatoryBowelDisease?
DanaDuricova
背景：基于人群的研究代表了患者人群的范围，并且应提供评估患者预后的主要依据。大部分克罗恩病患者在疾病过程中需要行手术治疗。炎症性肠病（包括溃疡性结肠炎和克罗恩病）的疾病过程是非常多样化而且不可预测的。
结论：克罗恩病的手术率随时间而降低。关于溃疡性结肠炎患者行结肠切除术概率的证据尚不确凿。溃疡性结肠炎及克罗恩病患者发生结直肠癌的相对风险约为背景人群的两倍，但是最近的队列研究表明该风险似乎正在降低。
Abstract
Background:Population-basedstudiesrepresentthewholespectrumofpatientpopulationandshouldrepresentthemainstaywhenevaluatingpatients’prognosis.AhighnumberofCDpatientsneedsurgicalinterventionduringthediseasecourse.Thediseasecourseofinflammatoryboweldiseases,includingulcerativecolitis(UC)andCrohn’sdisease(CD),isquitevariedandstillquiteunpredictable.
KeyMessages:Accordingtoearlierstudies,upto60%ofpatientsundergoatleastoneoperationafter10yearsofCDduration.Newercohortsreportlowercumulativeprobabilityofsurgeryofapproximately40%after10years.ThecolectomyrateinUCisapproximately10%after10yearsfromdiagnosiswithageographicdifference.SimilarlytoCD,thecolectomyrateseemstodecreaseovertime.Thereissomeevidencethattheincreasinguseofimmunosuppressiveand/orbiologicaltherapymighthavebeenresponsibleforthisfavourabletrend.However,otherfactorsmayhaveanimpactondecreasingsurgicaltrendovertime.Therelativerisk(RR)ofcolorectalcancer(CRC)inUCisapproximatelydoubled怎样能治好白癜风第一名白癜风医院
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